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Keynote
Presentations
Thirty Years of Gender and Technology Research: What have
we learnt and how can it be applied?
By Konrad Morgan
University of Bergen, Norway
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Abstract
This presentation reviews the scientific literature of the
past 30 years concerned with the individual difference of
gender, with particular emphasis on the use of Information
and Communications Technology. The presentation concentrates
on possible gender based psychological, social and
environmental differences and how these potential differences
might influence attitudes and behavioural performance with
regard to new technology. It is argued that these issues will
be of growing importance in the knowledge based society
envisioned by the European Union within a larger and
integrated Europe.
Many surveys of gender ratios in technology and engineering
education show fewer females entering these types of courses.
As a result of this gender ratio difference in education,
fewer females are employed in technology based commerce and
industry. This paper explores some of the reasons proposed
for this gender ratio difference and suggests actions that
can be taken to try and encourage females into technology
based education and industry.
Bio
Dr. Konrad Morgan
is Professor of Human Computer Interaction and leader of the
InterMedia research centre on Digital Learning and New Media
at the University of Bergen, Norway.His research interests
focus on understanding the human and social impact of
information and communications technology (ICT). His
scientific work includes a number of original contributions:
The first empirical evaluations and explanations of why direct
manipulation and graphical user interfaces are superior in
usability terms; Some of the first explanations of gender
differences and attitudes in ICT use; Revealing the role of
personality types in computer based behavior and finally, the
influence of early parental encouragement in later technology
competence and attitudes. During recent research leave from
his chair at Bergen he devoted himself to the issues of ICT as
aid to least developed countries and attempted to address some
of the most extreme gender imbalances in ICT by creating
opportunities and role models for females in the Middle East.
• In 2002 he held the chair of computer science and
information systems at the University of the South Pacific as
part of a Japanese sponsored ICT aid programme to the 12
nations of the South Pacific.
• In 2001 he held the chair of Computing at the prestigious
Abu Dhabi Women´s college in the United Arab Emirates (UAE)
where he helped introduce an accredited ICT education for
female UAE nationals in what can be an extremely male
dominated society.
He is currently chair of the Ethics and Equity taskforce for
the "Kaleidoscope" European Union Network of Excellence
devoted to digital learning.
His most recent book “Human Perspectives in the Internet
Society: Culture, Psychology, and Gender” by WIT press shows
his continuing concern for equity and understanding in the
digital environment.
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Modelling unreliable and untrustworthy behaviour in
norm-governed agent
societies
By
Marek Sergot
UK
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Abstract
It cannot always be assumed that agents will behave as they
are supposed to behave. In such cases it is often useful to
think of agent systems (of human or computer agents) as
governed by norms. Norms specify agents' obligations,
permissions, and rights, their responsibilities in regard to
the achievement of specific goals, and their powers to
initiate changes, to authorise, and to delegate. Agents may
fail to comply with system norms for several reasons. They
might do so deliberately, in open agent systems or other
competitive settings, or unintentionally, in unreliable
environments because of factors beyond their control. In
addition to analysing system properties that hold if
specifications/norms are followed correctly, it is also
necessary to predict, test, and verify the properties that
hold if system norms are violated, and to test the
effectiveness of introducing proposed control, enforcement,
and recovery mechanisms. (C+)++ is an extended form of the
action language C+ of Giunchiglia, Lee, Lifschitz, McCain, and
Turner, designed for representing norms of behaviour and
institutional aspects of (human or computer) societies. We
present the permission component of (C+)++ and then illustrate
on a simple example how it can be used in conjunction with
standard model checkers for temporal logics to verify system
properties in the case where agents cannot be assumed to
comply with system norms.
Bio
Marek Sergot is Professor of Computational Logic in the
Department of Computing, Imperial College London. He graduated
in Mathematics at the University of Cambridge and then worked
in mathematical modelling before joining Imperial College in
1979. His research is in logic for knowledge representation
and the specification of computer systems, with particular
interests in legal, temporal and normative reasoning, the
logic of action and agency, and the formal theory of
organizations. He has also been working on the application of
AI techniques in Biologoy. Sergot is the developer, with Peter
Hammond, of the logic programming system APES which was used
very widely in the 1980s to build a wide variety of expert
systems and other applications. With Robert Kowalski, he
developed the `event calculus', an approach for reasoning
about action and change within a logic programming framework,
which is still one of the standard techniques for temporal
reasoning in AI. Work on formal-logical models of legal and
normative reasoning, and their applications, has been a main
topic of research since 1979. In recent years this has
included contributions to the logic of norms, to formal
theories of complex normative relations such as duties and
rights, logics of delegation and authorisation, and
applications to organisational modelling, multi-agent systems,
the modelling of contracts and business processes, and
computer security. Sergot was a member of the recently
concluded EU FET Project ALFEBIITE, developing normative,
socio-cognitive and legal frameworks for societies of open (competitive)
computational agents. He is currently a member of the EU Working
Group iTrust on Trust Management in Dynamic Open Systems, and
of the EU IP project TrustCom concerned with trust and
contract management in large-scale distributed virtual
organisations. He is a former President of the International
Association for AI and Law.
eGovernment, eCitizen, and What's in Between
By Avigdor Gal
Faculty of Industrial Engineering & Management, Technion -
Israel Institute of Technology, Israel
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Abstract
Governments go online, providing electronic services to
citizens. Citizens go online, using means such as emails, SMS,
and chat rooms to communicate. In this presentation we shall
discuss the technological challenges that eGovernments and
eCitizens face in attempting to communicate. We shall present
the use of Web services, ontologies, and Knowledge Management
tools to enable governments rapid, flexible responses to
citizen needs on the one hand, and more active participation
of citizens in the democratic process, on the other hand.
During the presentation, we shall present results from two
active European 6th Framework projects in eGovernment, namely
TerreGov and QUALEG.
Bio
Dr. Avigdor Gal
is a faculty member at the Information Technology Engineering
group (Faculty of Industrial Engineering & Management) at the
Technion - Israel Institute of Technology. He received his
D.Sc. degree from the Technion in 1995 in the area of temporal
active databases. He has published more than 40 papers in
journals (e.g., Journal of the ACM and IEEE Transactions on
Knowledge and Data Engineering), books (Temporal Databases:
Research and Practice) and conferences (e.g., ER and CoopIS)
on the topics of information system architectures, active
databases, and temporal databases. Avigdor is a member of
IFCIS, the International Foundation of Cooperative Information
Systems, and the ACM and the IEEE computer society. He was a
General co-Chair of CoopIS'2000 and a Program co-Chair of
NGITS'2002 and CoopIS'2004. Avigdor has been a PC member of
VLDB'2002, SIGMOD'2003 and a Panel Chair of ER'2004. Avigdor
has a practical, as well as academic, experience with Internet
applications. He worked as a consultant with MyZebra.com, a
virtual enterprise specializing in customer service over the
Internet and he consults venture capital funds on new and
evolving technologies. Also, he has conducted research in the
area of data integration of federation of cooperative and
non-cooperative databases, with applications to Web-based
information services.
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Security and Trust in Information Society
By
Hussein Zedan
Montfort University at Leicester, UK
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Abstract
Ensuring the fubctionality, integrity and availability of
information is the key issue in the battle for Information
Superiority and thus is a decisive factor in modern warfare.
Security policies and security mechanisms govern the access to
information and other resources. Their correct specification
and enforcement are critical.
I will explore these notions and give a unifying framework
that combines functionality, security and temporal
requirements. Such a framework is sound and compositional
allowing the dynamic change of security policies according to
events and time.
Bio
Hussein Zedan is a Professor of Software Engineering at De
Montfort University (UK) and Director of the Software
Technology Research Laboratory, with over 20 years experience
as an academic and practitioner in Computer Science and IT
industry.
He is also the Technical Director of the University Technology
Centre (UTC) in Software Evolution, which is funded by
Software Migration Ltd. This is in addition to being on the
executive board of the Centre of Creative Technology (CCT), an
interdisciplinary centre involving Computing, Art and Design
and Humanities.
Hussein's work on the formal specification, verification,
validation and analysis of computing and information systems,
in particular those used in (time-, safety, mission-,
financial-)critical applications, has gained him an excellent
national and international reputation in the field.
He has published 4 books and over 100 technical papers and
articles in highly reputable journals and international
conferances.
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Native XML Databases: A Real-World Perspective
By Ronald Bourret
USA
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Abstract
Although they have been available for nearly six years, native
XML databases are just now gaining momentum in the real world.
This keynote is based on a broad survey of companies in the
field and looks at the problems users are solving with native
XML databases, as well as why they were unable to solve these
problems with relational or other technology.
Bio
Ronald Bourret is a freelance programmer, technical writer,
and researcher. His work includes XML-DBMS, a set of Java
packages for transferring data between XML documents and
relational databases, an XML schema language (DDML), several
widely read papers on XML and databases, and the XML
Namespaces FAQ. He has lectured on XML and databases at both
commercial and academic conferences and has contributed
articles to both XML.com and xmlhack.
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Unravelling the relationship between protein sequence,
structure and function: an intellectual and computational
challenge
By Anna Tramontano
University of Rome "La Sapienza", Italy
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Abstract
Proteins are the functioning molecules of living organisms,
they play key roles in most physiological processes such as
metabolism, transport, immune response, signal transduction,
or cell cycle. These linear polymers of amino acids perform
this impressive variety of functions by assuming a well
defined three-dimensional structure, which enables them to
accomplish highly specific molecular functions. In these
complex structures, amino acids that are far apart in the
linear sequence can come close together in space and
participate in the formation of highly specialized catalyitic
sites, ligand binding pockets or interfaces able to recognize,
bind and transmit information to other macromolecules.
Genomic projects are providing us with the linear amino acid
sequence of hundreds of thousands of proteins. If only we
could learn how each and every of them folds in
three-dimensions we would have the complete part list of an
organism and could face the challenge of understanding how
these parts assemble in a cell.
This is not only an intellectual challenge, it has enormous
practical implications. Malfunctioning of proteins is the most
common cause of endogenous diseases while the action of
pathogens is generally mediated by their proteins.
There are experimental methods that can provide us with the
knowledge of the precise arrangement of every atom of a
protein and with details about their functional properties,
but they are time consuming techniques and we cannot hope to
use them to understand the structure and function of all the
proteins of the universe. What stands in our way,
notwithstanding all these efforts, is the complexity of the
problem. However, we have at our disposal the experimentally
solved structures of a reasonable number of proteins, a few
thousands as of today. They represent solved instances of our
problem and we can hope to extract heuristic rules from their
analysis.
I will describes what we can learn from the analysis of known
protein structures and how this knowledge can be used to
attempt the prediction of the structure and function of the
remaining proteins.
Bio
Anna Tramontano was trained as a physicist but she soon became
fascinated by the complexity of biology and by the promises of
computational biology. She did her post-doc at the Department
of Biochemistry and Biophysics of UCSF where she collaborated
in the development of the very popular molecular graphics
software Insight. Later she was a staff scientist in the
Biocomputing Programme of the EMBL, where she studied the
sequence structure relationship in immunoglobulin molecules.
In 1990 she moved back to Italy in the Merck Research
Laboratories near Rome, where she was involved in protein
structure modeling and design, and in drug and vaccine
discovery and development. She recently returned to the
academic world and is now Chair Professor of Biochemistry in
"La Sapienza" University in Rome where she continues to pursue
her scientific interests on protein structure prediction and
analysis.
She is a member of the European Molecular Biology Organization
and a member of the board of Directors and past vice president
of the International Society of Computational Biology.
She is Associate Editor of Proteins, Bioinformatics and FEBS
Journal, member of the steering Committee of the EU funded
BioSapiens Network of Excellence, of the FEBS publication
Committee, of the organizing Committee of the Critical
Assesment of Techniques for Protein Structure Prediction (CASP)
initiative, of the Scientific Council of Institute Pasteur -
Fondazione Cenci Bolognetti.
In 2001, she received a prize from the Italian National
Academy of Science and in 2002 she was awarded the special
prize for Natural Sciences of the Italian Government.
Ethical Issues and health Informatics
By
Bernie Brenner
University of Otago, New Zealand
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Abstract
The address will cover current thoughts of ethical issues
pertaining to the use of computers in Medicine and especially
the internet. The paper will cover areas on
clinical consulting on the net, and the accreditation of
health sites.
The value of the net in acquiring knowledge on evidence based
medicine will be covered. Opposing views on alternative
medicine, medical tests on the net and the sale of
pharmaceutical agents via the net will all be discussed.
Bio
Bernie Brenner is in active clinical practice as a
gynaecologist in Auckland NZ. He has had an interest in ethics
that spans 3 decades. His educational background includes
medical degree from Witwatersrand University in Johannesburg
and he completed his specialist studies in Auckland. He has a
BA with Philosophy major from University of South Africa. He
has a post graduate Diploma in Professional Ethics from
Auckland University. His Doctoral Thesis from Southern Cross
University
included the design and use of computer expert systems and
Ethical Decision Making.
He has presented topics relating to Ethics at both National
and International Conferences. He has published several
articles on Ethics in peer reviewed journals.
He has run many successful workshops on Ethics and audiences
have included government departments, business managers,
students, and health care workers. He has been a regular guest
lecturer for Massey University covering areas of International
Business Ethics and Applied Ethics topics.
He has design a totally separate stand alone module on Ethics
for part of the University of Otago Health Informatics
diploma. He is a senior lecturer in this university as part of
its distance learning program. He is actively involved in the
South Pacific Islands teaching program of the University.
He is co-author of a textbook on "The Ethics of Health
Informatics". Bernie has an active and continuing interest in
teaching and running workshops all aspects of Ethics in
National and International Business, in Informatics, the
Computer industry and in all branches of Health Care Delivery
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Leurré.com: a worldwide distributed honeynet to build
early warning systems
By Marc Dacier
Institut Eurecom, France
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Abstract
For several months we have deployed the very same platform at
the premises of the networks of several partners located all
over the world. As of today, around 30 platforms in 20
countries covering the 5 continents have accepted, on a
voluntary basis, to participate to this experiment. By hosting
one of our honeypots, they are granted access to the whole
data set we have accumulated so far. In this presentation, we
will present the platform itself as well as some of the
results we have obtained thanks to detailed analysis carried
out by our team. The idea of this set up is not to capture so
called zero day attacks but, instead, to build long term
statistical data to model the threats occurring on the
Internet. We will highlight the differences that exist between
platforms and give examples of the level of sophistication
found in some of these attack processes. More detailed
information is available in the papers published in various
other conferences in the recent past, the references of which
are available on the following web page:
www.eurecom.fr/~pouget/papers.htm. This work is
partially funded in the context of the French National ACI
Security project entitled CADHO (http://acisi.loria.fr).
Bio
Marc Dacier received the degree of Ingénieur Civil en
Informatique from the University of Louvain, Belgium in 1989
and the Ph.D., European Label, from the Institut National
Polytechnique in Toulouse, France in 1994. From 1989 until
1991, he worked at the University of Louvain. From 1992 until
1994, he was a member of the dependability group, at LAAS-CNRS
in Toulouse, working in the "Dependable Computing and Fault
Tolerance" group on quantitative evaluation of operational
computer security. In 1995, he worked in Paris as a security
consultant. In 1996 he joined the IBM Zurich Research
laboratory. In 1997, he became the manager of the Global
Security Analysis Lab. The GSAL team pursued several projects
in the intrusion detection domain which led to the creation of
the new Tivoli Intrusion detection product, namely Tivoli Risk
Manager. Since 1997, he has ben giving, as an invited
researcher, an intrusion detection seminar at the University
of Louvain (UCL), Namur (FUNDP) and Liège (ULG) and also at
the ENSEEIHT in Toulouse. In 2002, he has received the title
of invited professor at UCL and associate professor at ULG. In
1998, he co-founded with Kathleen Jackson from the Los Alamos
National Lab, the symposium on "Recent Advances on Intrusion
Detection" (RAID). He is now chairing its steering committee.
He also was the co-director, with Brian Randell from the
University of Newcsastle, of the MAFTIA European Project. He
serves on the program committees of major security and
dependability conferences and is a member of the steering
committee of the "European Symposium on Research for Computer
Security" (ESORICS). He is a member of the editorial board of
the journal IEEE Transactions on Dependable and Secure
Computing. He has joined the Corporate Communications
Department at Eurecom in July 2002 as a professor. His
research and teaching interests include computer and network
security, intrusion detection, network and system management,
dependability in the presence of malicious faults. He is the
author of numerous international publications and several
patents.
A Model for Synchronous Learning Using the Internet
By
Nian-Shing Chen
National Sun Yat-sen
University,Taiwan
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Abstract
With the improvement in technology and increasing bandwidth of
Internet access, synchronous solutions for instruction are
becoming popular. They do not only provide savings in terms of
time and cost, but also outperform asynchronous online
instruction and even traditional face-to-face education in
many circumstances. But the lack of a pedagogical framework
for synchronous instruction has till now affected the
effective use of this medium. In this keynote, I will
introduce an online synchronous learning model that aims to
provide guidelines for teachers and students to conduct
synchronous instruction. The model provides a broad range of
scenarios to suit individual requirements and covers both
synchronous lecturing and 'office-hours' modes.
Bio
Dr. Chen is a Professor with the Department of Information
Management, National Sun Yat-sen University, Taiwan. and an
Adjunct Professor with the Griffith Institue for Higher
Education, Griffith University, Australia. He is also served
as the Director of Taiwan Computer Emergency Response
Team/Coordination Center (TWCERT/CC).
Dr. Chen received his Master Degree in Industrial Engineering
in 1986 and his Ph.D. Degree in Computer Science in 1990 from
National Tsing-Hua University.
Professor Chen is very keen to promote information technology
for education; he has devoted himself to designing a very
popular LMS (Learning Management System) since 1995. He also
made many efforts to enable colleges and K12 schools to adopt
E-learning for teaching and learning. Some of his efforts have
been well recognized, such as NSYSU Cyber University
http://cu.nsysu.edu.tw, AJET(Advanced Joint English
Telecommunication) http://ajet.nsysu.edu.tw and bK12 digital
school http://ds.k12.edu.tw. Professor Chen has been strongly
involved in the development of the Taiwan Academic Network
(TANet) for more than 14 years.
His publications include 35 journal papers, 87 articles in
academic Conferences, three books and 86 other publications.
His current research interests include assessing e-Learning
course performance; online synchronous live instruction;
e-Learning standards; mobile learning; IP-based
video-conferencing; knowledge management and information
system development methodology.
Dr. Chen is a member of IEEE and a member of IEEE Technical
Committee on Learning Technology
(http://lttf.ieee.org/contacts.htm).
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Social Presence and e-Learning
By Karen Swan
Kent State University, USA
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Abstract
“Social presence” can be defined as the ability of
participants in online discussions to both perceive other
participants as “real people” and to project themselves
socially and affectively into the discussion. This
presentation will explore the concept of social presence and
its relationship to learning online, through a review of
research studies to date investigating these topics, with a
particular emphasis on the presenter’s research.
Bio
Karen Swan is the Research Professor in the Research Center
for Educational Technology (RCET) at Kent State University.
Dr. Swan’s research has been in the general area of media and
learning. Her current research focuses on teaching and
learning in ubiquitous computing environments, mobile
technologies, and asynchronous learning networks. Her research
on online learning has particularly centered on interactivity,
social presence, and interface issues. Dr. Swan pioneered the
development of an online degree in Instructional Technology at
the University at Albany and taught several online courses for
the program. She is the Learning Effectiveness Editor
for the Sloan Consortium on Asynchronous Learning Networks,
the Special Issues Editor for the
Journal of Educational Computing Research,
and Editor of RCET’s own multimedia online journal,
the Journal of the Research Center for Educational Technology.
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IPv6 for mobile networks: Need or Hype?
By
Hesham Soliman
Flarion Technologies, USA
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Bio
Hesham Soliman is a member of the Advanced Networking group at
Flarion Technologies. He made numerous contributions to the
Mobile IPv6 protocol and related optimisations, as well as,
IPv6 and its applicability to cellular networks. He is a
member of several scientific committees for wireless and
mobility related conferences. Prior to his current role, he
was a senior specialist at Ericsson Research where he led
several research activities related to IPv6, mobility
management, and cellular networks. Hesham is also the author
of Mobile IPv6: Mobility in a wireless Internet,
Addison-Wesley.
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Developing Ubiquitous Medical Imaging Information System
Standard
By Sabah Mohammed
Advanced Technology and Academic Centre,
Lakehead University, Canada |
Abstract
Under pressure to improve the quality of patient care, reduce
errors, and reduce costs, the medical industry faces an
immediate need to change the way healthcare is delivered. This
means providing healthcare workers with tools and technologies
that deliver critical information at the point of care while
streamlining their workloads with secure and automated
functionality.
Armed with handheld ubiquitous devices, healthcare workers can
now use every minute of the day more productively to
streamline processes and get real-time data at the point of
care. This article presents a solution framework for designing
ubiquitous medical imaging information system based on JXTA
peer-to-peer technology along with representing the medical
data that includes multimedia or images as SVG. The security
issue of having the data as SVG where it represents an open
source XML files, is addressed. XML Encryption along with
lightweight encipherment techniques are introduced as
solutions for the security problem. The article also addresses
SVG metadata and annotation issues for better data retrieval
and interactivity based on RDF standard.
Bio
Dr. Mohammed received his B.Sc. in Applied Mathematics (
Baghdad University 1977), and his graduate degrees in Computer
Science from Glasgow University (MSc 1981), and Brunel
University (PhD 1986).
Since late 2001, Dr. Mohammed is an Associate Professor of
Computer Science at Lakehead University. Formerly, from
1986-1995, Dr. Mohammed was an Assistant/Associate Professor
of Computer Science at Baghdad University holding the position
of the Graduate Organizer in Computer Science. During
1996-2001, he served as the Chair of Computer Science at four
different universities: Amman University (1995-1996),
Philadelphia University (1996-1997), Applied Science
University (1997-2000), and Higher College of
Technology(2000-2001).
Dr. Mohammed has co-authored four text books in Compilers,
Artificial Intelligence, Java Programming and Applied Image
Processing, published over 70 refereed publications, was the
MSc advisor for 17 students and 1 PhD student, and has
received research support from a variety of governmental and
industrial organizations. Dr. Mohammed provided consultations
for a variety of organizations. Dr. Mohammed organized two
international conferences on Computers and their Applications
during 1997 (at Philadelphia University) and 1998 (at Applied
Science University) as well as a Regional Symposium on
eEducation during 2001 (at Higher College of Technology).
Dr. Mohammed's research interests include Medical Image
Processing, Multimedia Learning Objects, P2P Programming,
Image Lightweight Security, Artificial Intelligence and Fuzzy
Logic. Dr. Mohammed is also on the editorial boards of the
International Journal of Computing and Information Sciences,
Regional Editor of Journal of Information and Technology,
Regional Editor of the American Journal of Applied Science,
Member of the Editorial board of the International Arab
Journal of Information Technology and the Asian Journal of
Information Technology. Dr. Mohammed is a member of the
British Computer Society, member of the Canadian Image
Processing & Pattern recognition Society, Member of the IEEE
Signal Processing Society.
Selected Publications:
1. S. MOHAMMED, and J. FIAIDHI, Image Segmentation Based on
Light Intensity Growth and its Implementation in Java,
International Journal of Applied Science and Computation
(USA), Vol.11, No.1, April 2004, pp 10-17.
2. S. MOHAMMED, J. FIAIDHI, and L. YANG, Developing Multitier
Lightweight Techniques for Protecting Medical Images within
Ubiquitous Environments, IEEE 2nd Communications, Networks and
Service Research Conference (CNSR04), Fredericton, N.B.,
Canada, May 19-21, 2004.
3. S. MOHAMMED, L. YANG, and J. FIAIDHI, A Dynamic Fuzzy
Classifier for Detecting Abnormalities in Mammograms, IEEE 1st
Canadian Conference of Computer and Robot Vision (CRV04),
University of Western Ontario, London, Canada, May 17-19,
2004.
4. S. MOHAMMED, L. YANG, J. FIAIDHI and P. MAHANTI, Developing
a Mammography P2P Consultation System, The 2004 International
Conference on Imaging, Science and Systems (CISST04), Las
Vegas, Nevada, USA, June 21-24, 2004
5. S. MOHAMMED, and J. FIAIDHI, A Blackboard Model of Natural
Language Comprehension Using Data Mining, International
Conference of the IASTED on Computer Systems & Applications
(IASTED98), Irbid, HKJ, March 30- April 2, 1998.
6. S. MOHAMMED, R. NAOUM, and N. KASTO, An NP-Complete
Approach for Solving
Textile Allocation Problem, The IEEE International Conference
on
Information, Systems and Control (ICECS'95), Amman, HKJ, 17-21
Dec, 1995.
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Identification of Orthologous Genes Using Pairs of
Genome-Wide Unique Sequences
By
Ming-Jing Hwang
Institute of Biomedical Sciences, Academia Sinica, Taiwan
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Abstract
Identification of orthologous gene pairs in related species is
an essential objective of comparative genomics, as it
contributes to our understanding of the evolution of genes and
their functions. Most of the current approaches to
computational orthology identification rely greatly on
sequence similarity. These approaches typically require an
exhaustive “all-against-all” sequence alignment as an initial
step of the identification procedure.
We have developed a simple method that does not require
sequence alignment for gene orthology identification. In this
method we first identify all “uni-marker pairs”: 16-mer
sequences that occur exactly once in both genomes of the
compared species. Each pair of genes that contain identical
uni-markers is assigned an orthology score, encapsulating the
number of uni-markers contained, as well as their coverage
extent and orientation within the two genes. An empirical
p-value is provided as a measure of confidence in the
orthology score. Gene pairs with mutual best scores are
reported as orthologous pairs. We hypothesize that extensive
“uni-marker linkage” between a pair of genes provides a
significant evidence that the two genes have descended from a
common ancestral gene.
We have utilized this method to identify human - mouse gene
orthology. The resulting human-mouse orthologous gene pairs
were in good agreement with those included in the Mouse Genome
Database (MGD) at the Jackson Laboratory, and in NCBI’s
HomoloGene database. In addition, our method provides
alternative orthologous assignments, as well as new
orthologous pairs that have not been reported by MGD or
Homologene databases, many of those with low p-values.
Bio
I received a Ph.D. degree in Chemical Engineering from
University of Pittsburgh (Pittsburgh, PA) in 1989. I then
worked for Biosym Technologies Inc. (San Diego, CA) for five
years. At Biosym, I helped lead a team funded by a consortium
of pharmaceutical and chemical companies to develop a suite of
new-generation molecular energy functions for the simulation
and modeling of biological and chemical molecules. Since 1994
I have been a Principal Investigator for the Laboratory for
Bioinformatics and Biomolecule Modeling at the Institute of
Biomedical Sciences at the Academia Sinica. My laboratory has
produced a number of bioinformatics databases and software
tools (http://gln.ibms.sinica.edu.tw/software.php).
Selected Publication
1. Chen,
L.Y.Y., Lu, S.-H., Shih, E.S.C., Hwang, M.-J. (2002) “Single
Nucleotide Polymorphism Mapping Using Genome-wide Unique
Sequences,” Genome Research 12:1106-1111.
2. Yang,
J.M.,* Tsai, C.H., Hwang, M.-J.,* Tsai, H.K., Hwang J.K., Kao,
C.Y. (2002) “GEM: a Guassian Evolutionary Method for
Predicting Protein Side-chain Conformations,” Protein Sci.
11:1897-1907. (co-corresponding authors)
3. Shih,
E. S.C., Hwang, M.-J. (2003) "Protein Structure Comparison by
Probability-Based Matching of Secondary Structure Elements,"
Bioinformatics 19:735-741.
4. Shih,
E. S.C., Hwang, M.-J. (2004) "Alternative Alignments from
Comparison of Protein Structures," Proteins: Structure,
Function, and Bioinformatics 56:519-527.
5. Liao,
B.-Y., Chang, Y.-J., Ho, J.-M., Hwang, M.-J. (2004) “The
UniMarker (UM) method for synteny mapping of large genomes,”
Bioinformatics 20:3156-3165.
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Computers and cognition: Cognitive skills employed in
digital work
By
Yoram Eshet
Open University of Israel, Israel
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Abstract
The fast development in digital technologies during the
digital era confront individuals with situations that require
the utilization of an ever-growing assortment of
cognitive skills that are utilized in executing tasks in
digital environments, such as surfing the web, deciphering
user interfaces, working with databases, participating in
Internet forums, and chatting in chat rooms. In the digital
era, these skills have become real "survival skills that help
users to work intuitively in executing complex digital tasks.
Eshet (2004) published a conceptual cognitive, holistic model
for the term digital literacy, a model that complements
existing, but incomplete models (e.g. Burnett & McKinley,
1998; Zins, 2000; Hargittai, 2002), that are usually
local, focusing on a limited variety of digital skills, mainly
information-seeking skills. Eshet has argued that his model
covers most of the cognitive skills that users and scholars
employ in digital environments and, therefore, provides
researchers and designers of digital environments with
powerful framework and design guidelines. The six
digital literacy cognitive skills of Eshet are:
Photo-visual skills:
The ability of users to “use vision to think”, and to
communicate effectively with digital environments through
visual representations of information (Tuft, 1990). These
skills are utilized mainly in designing and working with
graphic user interfaces.
Reproduction skills:
The ability to use digital technologies in order to create new
meanings or new interpretations by combining preexisting,
independent shreds of information (Benjamin, 1994) in any form
of media (text, graphic, or sound). These skills are employed
in writing digital texts and in designing graphical displays
with digital editing tools.
Branching skills:
The ability of users of digital environments to seek
information and construct knowledge in non-linear digital
environments. These skills are crucial for effective surfing
and knowledge creation from databases and the Internet .
Information skills:
The ability of digital information consumers to analyze,
evaluate and assess information (e.g. Burnett & McKinley,
1998; Zins, 2000). Information skills act as a filter: They
identify false, irrelevant, or biased information, and avoid
their penetration into the learner’s cognition. Information
skills are utilized in almost any work with digital
environments that involve information, as news resources,
databases and the Internet. In the digital era, with the
unlimited exposure to information, these skills have become
"survival skills" for modern users.
Socio-emotional skills:
The ability of users to employ sociological and emotional
skills in order to perform effectively in digital
communication environments, as knowledge-sharing groups,
discussion groups, knowledge communities, chat rooms, and any
other form of collaborative learning (Amichai-Hamburger,
2002).
Synchronic skills:
The ability of users to process simultaneously large volumes
of information that are provided by digital environments.
These skills are utilized mainly in computer games and
multimedia learning environments, which provide simultaneous
audio-visual stimuli, and challenge the user with the need to
synchronize them in order to work effectively.
The present paper reports on a pioneering research that was
designated to examine the performance of users of different
age groups with tasks that require the utilization of the
different types of cognitive skills described above. The
research’s basic assumption is that the level of digital
literacy is affected mainly by the cognitive developmental
stage and experience of users and, hence, the hypothesis is
that differences in digital skills would be found for
different age and gender groups (Hargittai, 2002) of similar
background and experience. Until today, very little empirical
information is available on digital literacy skills of
different ages and genders, and the present research's results
may shed light on this relatively new assortment of cognitive
skills that learners cope with in the digital era. Results
will improve our understanding of users' needs under different
digital situations and provide educators and designers of
digital environments with powerful guidelines in designing
better user-oriented digital environments.
References cited
·
Amichai-Hamburger, Y. (2002). Internet and personality.
Computers in Human Behavior, 18: 1-10.
·
Benjamin W. (1994). The Work of Art in the Age of Technical
Reproduction (Hebrew translation from German). Tel
Aviv: Teamin Publishers.
·
Burnett, K., & McKinley, E.G. (1998). Modeling information
seeking. Interacting With Computers, 10: 285-302.
·
Eshet, Y. (2004). Digital literacy: A conceptual
framework for survival skills in the digital era. Journal
of Educational Multimedia and Hypermedia, 13(1): 93-106
.
·
Hargittai, E. (2002). Beyond logs and surveys: In-depth
measures of people's Web use skills. Journal of the
American Society for Information Science and Technology, 53
(14): 1239-1244.
·
Tuft, E.R., (1990). Envisioning Information. Graphic
Press, Cheshire, CT.
·
Zins, C. (2000). Success, a structured search strategy
rationale, principles and implications. Journal of the
American Society for Information Science, 51: 1232-1247
Bio
My academic education is variegated: Archeology & geography
(B.A.-1977) and geology & Environmental Sciences (M.Sc.-1982 &
Ph.D-1987.).
My professional experience is also variegated, lying between
geology research and educational technology research and
development. For the last 15 years I devoted my career
to researching and developing technology-based instructional
materials in computer companies and in the academia. At the
same time, I was a part-time senior researcher at the
geological survey of Israel. Today I'm an Assoc. Prof.
and a faculty member at the Open University of Israel (Dep. Of
Pssychology & Education). I'm the Head of the Chais Research
Center of Educational Technologies and the Head of the
Instructional Technologies Dep. In the Tel Hai Academic
College.
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Andes intelligent physics
tutoring system: Lessons learned
By
Kurt VanLehn
University of Pittsburgh, USA
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Abstract
It is difficult to fit innovative educational technology into
the ordinary practices of instructors, unless the instructors
themselves developed the technology. On the other hand,
almost all instructors are eager to delegate grading of
homework exercises, as long as they can continue to assign the
exercises that they prefer. Thus, web-based homework grading
services are a rapidly growing type of educational technology. The
Andes intelligent tutoring system (www.andes.pitt.edu) takes
this success one step further. It is a homework helper, and
not just a grader. Instead of solving physics homework
problems on paper and entering the answer into a homework
grading service, students do all their work on the Andes user
interface. The user interface is intended to be as
unconstraining as a piece of paper. However, unlike paper, it
provides immediate feedback on every user action, thus
preventing mistakes from proliferating and wasting students'
time. Students may also ask for help, and frequently do so
when they do not see immediatly how to fix an error. Andes
then gives them a sequence of increasingly specific hints
until they can correct their error and continue solving the
problem. Andes has been evaluated in five semester-long
evaluations at the United States Naval Academy. Students who
did their homework on Andes scored significantly higher on
exams than students who do the same homework problems on paper. This
talk describes Andes, the evaluations, and what was learned
about the process of developing a successful homework helper.
Bio
Dr. VanLehn is as a Professor of Computer Science, a Senior
Scientist at the Learning Research and Development Center, and
Director of CIRCLE ,
an NSF Center. He received a BS from Stanford (Mathematics,
1974) and a PhD from MIT (Computer Science, 1983). He was a
Research Associate at Xerox Palo Alto Research Center until
1985, when he joined Carnegie-Mellon University as an
Assistant Professor of Computer Science and Psychology. He
moved to the University of Pittsburgh in 1990.
Dr. VanLehn's research interests focus on applications of
artificial intelligence to education and cognitive modeling.
At this writing, he is engaged in 3 research projects.
Circle is an
NSF-supported research center that is finding out why human
tutoring is so effective and building computer tutors that
will equal or even exceed their effectiveness. Circle is a
collaborative effort involving 9 professors from CMU and Pitt.
The Andes
project is developing an intelligent tutoring system that
helps college students learn physics. It features 3 novel help
systems and a student modeling component based on Bayesian
networks. The
Why2000
project is developing a natural-language based tutoring system
for help student learn how to explain "why" physical systems
work the way they do.
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Consolidating Memory Status through Sleep Stages
By
Piet Kommers
University of Twente, The
Netherlands
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Abstract
The transition from retained information into active knowledge
for further problem solving has not been understood well. Once
learning new skills and knowledge ocurred in a conscious way,
certain sleep stages help to make the learned more durable and
more flexible.
The conscious element has been recognized as meta-knowledge:
the awareness of what you know. However the effects of non-rem
sleep for the persistence of declarative knowledge heas been
underestimated until recently.
Bio
Dr. Piet Kommers is associate professor in media technology in
the University of Twente in the Netherlands and Lector at
Fontys Academy in Eindhoven. His research interest is the
further specification of media design methodologies for
learning and training situations. His leadership of the 1992
NATO Advanced Research Workshop on Cognitive Learning Tools
raised the global attention for constructivist elements in
complex learning. He was initiator of a large number of
international projects on media scenarios for the further
development of training and educational institutes. His
current
research into WWW-based Learning Communities and the role of
Virtual Reality in the sharing of experiences in complex
situations like medical and technological interventions has
earned a wide recognition so far. Dr. Kommers is associate
editor of the International Journal for Continuous Engineering
Education and Life-long Learning and he is executive editor of
the International Journal for WWW-based Communities.
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